A study by Niwa et al. shows that changes in the levels of the transcription factor Oct-4 regulate the differentiation of embryonic stem cells along three different pathways. These observations suggest a possible mechanism by which Oct-4 determines the formation of the mouse pre-implantation embryo.
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Stewart, C. Oct-4, Scene 1: the drama of mouse development. Nat Genet 24, 328–330 (2000). https://doi.org/10.1038/74129
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DOI: https://doi.org/10.1038/74129
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