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Inhibition and plasticity

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A study of ocular dominance plasticity in mice lacking a synthetic enzyme for GABA suggests that increased cortical inhibition initiates the critical period for plasticity in primary visual cortex.

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Figure 1: Time course of the critical period for ocular dominance plasticity elicited by short-term monocular deprivation in the mouse.
Figure 2: Speculative model for gating of critical period onset by inhibition.

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  1. the Neural Development Section, NINDS/NIH , Bldg. 36 Rm. 2CO2, MSC 4066, 36 Convent Dr., Bethesda, 20892, Maryland, USA

    Daniel E. Feldman

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  1. Daniel E. Feldman
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Feldman, D. Inhibition and plasticity. Nat Neurosci 3, 303–304 (2000). https://doi.org/10.1038/73849

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