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Axin and hepatocellular carcinomas

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A gene (AXIN1) encoding another component of the Wnt-signalling pathway is reported to be mutated in human tumours, underscoring the oncogenic consequences of inappropriate activation of developmental signalling pathways later in life. Inhibitors of these signals therefore represent potential agents with which to treat cancer.

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Figure 1
Figure 2: Schematic representation of the Wnt-signalling cascade.

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Authors and Affiliations

  1. Department of Immunology, University Hospital and Centre for Biomedical Genetics, Utrecht, The Netherlands

    Hans Clevers

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  1. Hans Clevers
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Clevers, H. Axin and hepatocellular carcinomas. Nat Genet 24, 206–208 (2000). https://doi.org/10.1038/73396

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