Cannabinoid agonists arrest tumor progression in a rodent model of malignant glioma. Will these molecules provide a starting point for new strategies for anti-cancer therapy (313–319)?
References
Christison, R. in A Dispensatory, or Commentary on the Pharmacopoeias of Great Britain (and the United States) 971–974 (Lea and Blanchard, Philadelphia, 1848).
Adams, R. Marihuana. Harvey Lect. 37, 168 ( 1941).
Gaoni, Y. & Mechoulam, R. Isolation, structure and partial synthesis of an active constituent of hashish. J. Am. Chem. Soc. 86, 1646–1647 ( 1964).
Matsuda, L.A., Lolait, S.J., Brownstein, M.J., Young, A.C. & Bonner, T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346, 561–564 (1990).
Piomelli, D., Beltramo, M., Giuffrida, A. & Stella, N. Endogenous cannabinoid signaling. Neurobiol. Disease, 5 462–473 (1998).
Galve-Roperh, I. et al. Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation . Nature Med. 6, 313–319 (2000).
Matsuda, L.A. Molecular aspects of cannabinoid receptors. Critical Rev. Neurobiol. 11, 143–166 ( 1997).
Kolesnick, R.N. & Krönke, M. Regulation of ceramide production and apoptosis. Annu. Rev. Physiol. 60, 643–665 (1998).
Avgeropoulos, N.G. & Batchelor, T.T. New treatment strategies for malignant gliomas. Oncologist 4, 209–224 (1999).
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Piomelli, D. Pot of gold for glioma therapy. Nat Med 6, 255–256 (2000). https://doi.org/10.1038/73088
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DOI: https://doi.org/10.1038/73088
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