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Neurodegeneration in the polyglutamine diseases: Act 1, Scene 1

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Abstract

A mouse model of the neurodegenerative disease spinocerebellar ataxia type 1 reveals that changes in gene expression begin many weeks before the onset of symptoms.

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Figure 1: Pre- and postsynaptic neurons, with intervening synaptic cleft.

(courtesy of D. Leja).

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Authors and Affiliations

  1. National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, 20892, Maryland, USA

    Robert Nussbaum & Georg Auburger

Authors
  1. Robert Nussbaum
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  2. Georg Auburger
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Nussbaum, R., Auburger, G. Neurodegeneration in the polyglutamine diseases: Act 1, Scene 1. Nat Neurosci 3, 103–104 (2000). https://doi.org/10.1038/72042

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