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Complexity and specificity of integrin signalling

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Abstract

The α-subunits of integrins — transmembrane adhesion proteins — associate with particular transmembrane and cytoplasmic proteins, providing a mechanism for the activation of specific intracellular signalling pathways by individual integrins.

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Figure 1: The major signalling pathways activated by integrins through their α-subunits.

References

  1. Hynes, R. O. Dev. Biol. 180, 402–412 (1996).

    Article  CAS  Google Scholar 

  2. Giancotti, F. G. & Ruoslahti, E. Science 285, 1028–1032 (1999).

    Article  CAS  Google Scholar 

  3. Liu, S. et al. Nature 402, 676–681 (1999).

    Article  CAS  Google Scholar 

  4. Chan, B. M. C. et al. Cell 68, 1051–1060 (1992).

    Article  CAS  Google Scholar 

  5. Arroyo, A. G., Yang, J. T., Rayburn, H. & Hynes, R. O. Cell 85, 997–1008 (1996).

    Article  CAS  Google Scholar 

  6. Kil, S. H., Krull, C. E., Cann, G., Clegg, D. & Bronner-Fraser, M. Dev. Biol. 202, 29–42 (1998).

    Article  CAS  Google Scholar 

  7. Ilic, D. et al. Nature 377, 539–544 (1995).

    Article  CAS  Google Scholar 

  8. Fincham, V. J. & Frame, M. C. EMBO J. 17, 81–92 (1998).

    Article  CAS  Google Scholar 

  9. Kaplan, D. B., Swedlow, J. R., Morgan, D. O. & Varmus H. E. Genes Dev. 9, 1505–1517 (1995).

    Article  CAS  Google Scholar 

  10. Turner, C. E. et al. J. Cell Biol. 145, 851–863 (1999).

    Article  CAS  Google Scholar 

  11. Manser, E. et al. Mol. Cell 1, 183–192 (1998).

    Article  CAS  Google Scholar 

  12. Angers-Loustau, A. et al. J. Cell Biol. 144, 1019–1031 (1999).

    Article  CAS  Google Scholar 

  13. Wary, K. K., Mariotti, A., Zurzolo, C. & Giancotti, F. G. Cell 94, 625–634 (1998).

    Article  CAS  Google Scholar 

  14. Hemler, M. E. Curr. Opin. Cell Biol. 10, 578–585 (1998).

    Article  CAS  Google Scholar 

  15. Frazier, W. A. et al. J. Biol. Chem. 274, 8554–8560 (1999).

    Article  CAS  Google Scholar 

  16. Lindberg, F. P. et al. Science 274, 795–798 (1996).

    Article  CAS  Google Scholar 

  17. Mainiero, F. et al. EMBO J. 14, 4470–4481 (1995).

    Article  CAS  Google Scholar 

  18. Agrez, M., Chen, A., Cone, R. I., Pytela, R. & Sheppard, D. J. Cell Biol. 127, 547–556 (1994).

    Article  CAS  Google Scholar 

  19. Fornaro, M. & Languino, L. R. Matrix Biol. 16, 185–193 (1997).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. the Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, Box 216, 1275 York Avenue, New York, 10021, New York, USA

    Filippo G. Giancotti

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  1. Filippo G. Giancotti
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Giancotti, F. Complexity and specificity of integrin signalling. Nat Cell Biol 2, E13–E14 (2000). https://doi.org/10.1038/71397

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