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Getting in shape with Rho

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Abstract

The Rho GTPases are potent regulators of the actin cytoskeleton and consequently influence many aspects of cell shape and movement. In vivo, Rho activity appears to be a critical determinant of tissue morphogenesis during several stages of embryonic development.

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Figure 1: In Drosophila development, the Rho GTPase mediates signalling pathways that direct several distinct morphogenetic processes.

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Authors and Affiliations

  1. the Department of Medicine, Harvard Medical School, and the Cancer Center of Massachusetts General Hospital, Building 149, 13th Street, Charlestown, 02129, Massachusetts, USA

    Jeffrey Settleman

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  1. Jeffrey Settleman
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Settleman, J. Getting in shape with Rho. Nat Cell Biol 2, E7–E9 (2000). https://doi.org/10.1038/71390

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