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QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2

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Figure 1: EAE susceptibility of NOD congenic mice.

References

  1. Encinas, J.A. et al. J. Immunol. 157, 2186– 2192 (1996).

    CAS  PubMed  Google Scholar 

  2. Sundvall, M. et al. Nature Genet. 10, 313– 317 (1995).

    Article  CAS  Google Scholar 

  3. Todd, J.A. et al. Nature 351, 542–547 (1991).

    Article  CAS  Google Scholar 

  4. Ghosh, S. et al. Nature Genet. 4, 404– 409 (1993).

    Article  CAS  Google Scholar 

  5. Vyse, T.J. & Todd, J.A. Cell 85, 311 –318 (1996).

    Article  CAS  Google Scholar 

  6. Podolin, P.L. et al. Mamm. Genome 9, 283– 286 (1998).

    Article  CAS  Google Scholar 

  7. Denny, P. et al. Diabetes 46, 695–700 (1997).

    Article  CAS  Google Scholar 

  8. Bernard, C.C. et al. J. Mol. Med. 75, 77– 88 (1997).

    Article  CAS  Google Scholar 

  9. Chesnut, K., She, J.X., Cheng, I., Muralidharan, K. & Wakeland, E.K. Mamm. Genome 4, 549– 554 (1993).

    Article  CAS  Google Scholar 

  10. Teuscher, C., Wardell, B.B., Lunceford, J.K., Michael, S.D. & Tung, K.S. J. Exp. Med. 183, 631–637 (1996).

    Article  CAS  Google Scholar 

  11. Matesanz, F., Alcina, A. & Pellicer, A. Immunogenetics 38, 300– 303 (1993).

    Article  CAS  Google Scholar 

  12. Classen, J.B. & Shevach, E.M. Autoimmunity 15, 55–59 (1993).

    Article  CAS  Google Scholar 

  13. Lenardo, M.J. et al. Int. Rev. Immunol. 13, 115– 134 (1995).

    Article  CAS  Google Scholar 

  14. Sadlack, B. et al. Eur. J. Immunol. 25, 3053– 3059 (1995).

    Article  CAS  Google Scholar 

  15. Zamvil, S. et al. Nature 317, 355–358 (1985).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank A. Abbas and L. Nicholson for review of the manuscript. These studies were carried out with the support of grants from the National Institutes of Health (RO1 NS 30843, RO1 NS 35685 and PO1 AI 39671) and National Multiple Sclerosis Society (RG 2571 and 2320) to V.K.K.

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Author notes

  1. C.E.S. and J.G.S. are supported by Howard Hughes Medical Institute.

Authors and Affiliations

  1. Department of Medicine, Center for Neurologic Diseases, Brigham & Women's Hospital, Boston, 02115, Massachusetts , USA

    Jeffrey A. Encinas, Akiko Mukasa, Howard L. Weiner & Vijay K. Kuchroo

  2. Department of Autoimmune Diseases Research, Merck Research Laboratories, Rahway, 07065, New Jersey, USA

    Linda S. Wicker

  3. Department of Cellular and Molecular Pharmacology, Merck Research Laboratories, Rahway, 07065, New Jersey, USA

    Laurence B. Peterson

  4. Department of Veterinary Pathobiology, The University of Illinois at Urbana–Champaign, Urbana, 61802, Illinois , USA

    Cory Teuscher

  5. Department of Pathology, Stanford University School of Medicine and Laboratory Service, Veterans Affairs Medical Center, Palo Alto, 94304, California, USA

    Raymond Sobel

  6. Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, 02115, Massachusetts, USA

    Christine E. Seidman & J.G. Seidman

Authors
  1. Jeffrey A. Encinas
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  2. Linda S. Wicker
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  3. Laurence B. Peterson
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  4. Akiko Mukasa
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  5. Cory Teuscher
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  6. Raymond Sobel
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  7. Howard L. Weiner
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  8. Christine E. Seidman
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  9. J.G. Seidman
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  10. Vijay K. Kuchroo
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Corresponding author

Correspondence to Vijay K. Kuchroo.

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Encinas, J., Wicker, L., Peterson, L. et al. QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2. Nat Genet 21, 158–160 (1999). https://doi.org/10.1038/5941

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