Skip to main content
Log in

Organic chemistry

Molecular structure assignment simplified

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

An innovative combination of chemical synthesis, theory and spectroscopy could simplify determination of the structures of naturally occurring, biologically active molecules, which are often leads for drug discovery. See Letter p.436

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Previously proposed and actual molecular structures of the baulamycins.

Notes

  1. See all news & views

References

  1. Hanessian, S. Natural Products in Medicinal Chemistry (Wiley, 2014).

    Book  Google Scholar 

  2. Wu, J. et al. Nature 547, 436–440 (2017).

    Article  CAS  Google Scholar 

  3. Tripathi, A. et al. J. Am. Chem. Soc. 136, 1579–1586 (2014).

    Article  CAS  Google Scholar 

  4. Guchhait, S., Chatterjee, S., Ampapathi, R. S. & Goswami, R. K. J. Org. Chem. 82, 2414–2435 (2017).

    Article  CAS  Google Scholar 

  5. Nicolaou, K. C. & Snyder, S. A. Angew. Chem. Int. Edn 44, 1012–1044 (2005).

    Article  CAS  Google Scholar 

  6. Neuhaus, D. & Williamson, M. P. The Nuclear Overhauser Effect in Structural and Conformational Analysis 2nd edn (Wiley, 2000).

    Google Scholar 

  7. Jones, C. R., Butts, C. P. & Harvey, J. N. Beilstein J. Org. Chem. 7, 145–150 (2011).

    Article  CAS  Google Scholar 

  8. Burns, M. et al. Nature 513, 183–188 (2014).

    Article  ADS  CAS  Google Scholar 

  9. Luo, Z., Zhang, Q., Oderaotoshi, Y. & Curran, D. P. Science 291, 1766–1769 (2001).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Thomas R. Hoye.

Related links

Related links

Related links in Nature Research

Antibiotics: An irresistible newcomer

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Thompson, S., Hoye, T. Molecular structure assignment simplified. Nature 547, 410–411 (2017). https://doi.org/10.1038/547410a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/547410a

  • Springer Nature Limited

Navigation