The development of a protocol for isolating and expanding the cell population that lines bile ducts has enabled the in vitro generation of bioengineered ducts. These can replace native bile ducts when transplanted into mice.
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References
Balistreri, W. F. et al. Hepatology 23, 1682–1692 (1996).
Sampaziotis, F. et al. Nature Med. http://dx.doi.org/10.1038/nm.4360 (2017).
Sampaziotis, F. et al. Nature Biotechnol. 33, 845–852 (2015).
Ogawa, M. et al. Nature Biotechnol. 33, 853–861 (2015).
Cardinale, V. et al. Nature Rev. Gastroenterol. Hepatol. 9, 231–240 (2012).
Auth, M. K. H. et al. Hepatology 18, 546–555 (1993).
Clevers, H. Cell 165, 1586–1597 (2016).
Miyazawa, M. et al. Am. J. Transplant. 5, 1541–1547 (2005).
Ji, S., Zhang, L. & Hui, L. J. Cell. Biochem. 114, 256–265 (2013).
Takebe, T. et al. Nature 499, 481–484 (2013).
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Zhang, L., Hui, L. Bile ducts regenerated. Nature 547, 171–172 (2017). https://doi.org/10.1038/547171a
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DOI: https://doi.org/10.1038/547171a
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