A paper that analysed genetic variants in 14,000 people to identify disease-associated regions set the standard for collaborative genome-wide association studies and provided methodological advances whose effects are still felt today.
Notes
References
The Wellcome Trust Case Control Consortium. Nature 447, 661–678 (2007).
Hirschhorn, J. N., Lohmueller, K., Byrne, E. & Hirschhorn, K. Genet. Med. 4, 45–61 (2002).
Klein, R. J. et al. Science 308, 385–389 (2005).
Hindorff, L. A. et al. Proc. Natl Acad. Sci. USA 106, 9362–9367 (2009).
Manolio, T. A., Brooks, L. D. & Collins, F. C. J. Clin. Invest. 118, 1590–1605 (2008).
Mossman, K. Sci. Am. 298, 42 (2008).
Summerskill, W. Lancet 371, 370–371 (2008).
Warren, H. R. et al. Nature Genet. 49, 403–415 (2017).
Marchini, J., Howie, B., Myers, S., McVean, G. & Donnelly, P. Nature Genet. 39, 906–913 (2007).
Homer, N. et al. PLoS Genet. 4, e1000167 (2008).
Popejoy, A. B. & Fullerton, S. M. Nature 538, 161–164 (2016).
Evans, D. S. et al. Hum. Mol. Genet. 25, 4350–4368 (2016).
Cade, B. E. et al. Am. J. Respir. Crit. Care Med. 194, 886–897 (2016).
Chan, S. L., Jin, S., Loh, M. & Brunham, L. R. Pharmacogenomics 16, 1161–1178 (2015).
Price, A. L., Spencer, C. C. A. & Donnelly, P. Proc. R. Soc. B 282, 20151684 (2015).
Author information
Authors and Affiliations
Corresponding author
Related links
Rights and permissions
About this article
Cite this article
Manolio, T. A decade of shared genomic associations. Nature 546, 360–361 (2017). https://doi.org/10.1038/546360a
Published:
Issue Date:
DOI: https://doi.org/10.1038/546360a
- Springer Nature Limited
This article is cited by
-
Attitudes among South African university staff and students towards disclosing secondary genetic findings
Journal of Community Genetics (2021)
-
A scientometric review of genome-wide association studies
Communications Biology (2019)
-
Genetic disease risks can be misestimated across global populations
Genome Biology (2018)