Stem-cell divisions are thought to be essential to tumour growth. Targeted removal of a specific stem-cell population reveals its role in tumour development and in the growth of tumours formed by cell migration to distant sites. See Article p.676
This is a preview of subscription content, log in via an institution to check access.
Notes
References
Nassar, D. & Blanpain, C. Annu. Rev. Pathol. 11, 47–76 (2016).
Visvader, J. E. & Clevers, H. Nature Cell Biol. 18, 349–355 (2016).
Barker, N. et al. Nature 457, 608–611 (2009).
de Sousa e Melo, F. et al. Nature 543, 676–680 (2017).
Buczacki, S. J. A. et al. Nature 495, 65–69 (2013).
Tetteh, P. W. et al. Cell Stem Cell 18, 203–213 (2016).
Tian, H. et al. Nature 478, 255–259 (2011).
Tetteh, P. W., Farin, H. F. & Clevers, H. Trends Cell Biol. 25, 100–108 (2015).
Schwitalla, S. et al. Cell 152, 25–38 (2013).
Davis, H. et al. Nature Med. 21, 62–70 (2015).
Schepers, A. G. et al. Science 337, 730–735 (2012).
Shimokawa, M. et al. Nature http://dx.doi.org/10.1038/nature22081 (2017).
Junttila, M. R. et al. Sci. Transl. Med. 7, 314ra186 (2015).
Author information
Authors and Affiliations
Corresponding author
Related links
Rights and permissions
About this article
Cite this article
Greten, F. Tumour stem-cell surprises. Nature 543, 626–627 (2017). https://doi.org/10.1038/543626a
Published:
Issue Date:
DOI: https://doi.org/10.1038/543626a
- Springer Nature Limited
This article is cited by
-
Cytokines, breast cancer stem cells (BCSCs) and chemoresistance
Clinical and Translational Medicine (2018)