Skip to main content
SpringerLink
Log in

Physiology

Stressed-out chromatin promotes longevity

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

Two studies reveal that early-life malfunction in organelles called mitochondria brings about lasting changes in how DNA is packaged. These alterations have consequences for cellular stress responses and organismal longevity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Coordinated responses to mitochondrial stress.

Notes

  1. See all news & views

References

  1. Dillin, A., Crawford, D. K. & Kenyon, C. Science 298, 830–834 (2002).

    Article  ADS  CAS  Google Scholar 

  2. Rea, S. L., Ventura, N. & Johnson, T. E. PLoS Biol. 5, e259 (2007).

    Article  Google Scholar 

  3. Haynes, C. M. & Ron, D. J. Cell Sci. 123, 3849–3855 (2010).

    Article  CAS  Google Scholar 

  4. Durieux, J., Wolff, S. & Dillin, A. Cell 144, 79–91 (2011).

    Article  CAS  Google Scholar 

  5. Tian, Y. et al. Cell 165, 1197–1208 (2016).

    Article  CAS  Google Scholar 

  6. Merkwirth, C. et al. Cell 165, 1209–1223 (2016).

    Article  CAS  Google Scholar 

  7. Haynes, C. M., Petrova, K., Benedetti, C., Yang, Y. & Ron, D. Dev. Cell 13, 467–480 (2007).

    Article  CAS  Google Scholar 

  8. Chang, H.-W., Shtessel, L. & Lee, S. S. Free Radic. Biol. Med. 78, 168–178 (2015).

    Article  CAS  Google Scholar 

  9. Labbadia, J. & Morimoto, R. I. Mol. Cell 59, 639–650 (2015).

    Article  CAS  Google Scholar 

  10. Schroeder, E. A., Raimundo, N. & Shadel, G. S. Cell Metab. 17, 954–964 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Siu Sylvia Lee is in the Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14850, USA.,

    Siu Sylvia Lee

  2. Jessica K. Tyler is in the Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York 10065, USA.,

    Jessica K. Tyler

Authors
  1. Siu Sylvia Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jessica K. Tyler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Siu Sylvia Lee or Jessica K. Tyler.

Related links

Related links

Related links in Nature Research

Cell biology: Form follows function for mitochondria

Ageing: A stretch in time

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lee, S., Tyler, J. Stressed-out chromatin promotes longevity. Nature 534, 625–626 (2016). https://doi.org/10.1038/534625a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/534625a

  • Springer Nature Limited

Search

Navigation