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Drug discovery

Fighting evolution with chemical synthesis

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A synthetic strategy has been developed that provides easy access to structurally diverse analogues of naturally occurring antibiotics, providing a fresh means of attack in the war against drug-resistant bacteria. See Article p.338

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Figure 1: A modular approach to macrolide synthesis.

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References

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Authors and Affiliations

  1. Ming Yan and Phil S. Baran are in the Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.,

    Ming Yan & Phil S. Baran

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  1. Ming Yan
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  2. Phil S. Baran
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Correspondence to Phil S. Baran.

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Yan, M., Baran, P. Fighting evolution with chemical synthesis. Nature 533, 326–327 (2016). https://doi.org/10.1038/533326a

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