Cutting-edge experiments show that the hormone leptin, which is secreted by fat cells, promotes fat loss by activating the release of catecholamine signalling molecules from neurons wrapped around the fat cells.
This is a preview of subscription content, log in via an institution to check access.
Notes
References
Zeng, W. et al. Cell 163, 84–94 (2015).
Zhang, Y. et al. Nature 372, 425–432 (1994).
Friedman, J. M. & Halaas, J. L. Nature 395, 763–770 (1998).
Bartness, T. J., Liu, Y., Shrestha, Y. B. & Ryu, V. Front. Neuroendocrinol. 35, 473–493 (2014).
Chung, K. et al. Nature 497, 332–337 (2013).
Ke, M.-T., Fujimoto, S. & Imai, T. Nature Neurosci. 16, 1154–1161 (2013).
Sharpe, J. et al. Science 296, 541–545 (2002).
Sohal, V. S., Zhang, F., Yizhar, O. & Deisseroth, K. Nature 459, 698–702 (2009).
Atasoy, D., Aponte, Y., Su, H. H. & Sternson, S. M. J. Neurosci. 28, 7025–7030 (2008).
Gettys, T. W., Harkness, P. J. & Watson, P. M. Endocrinology 137, 4054–4057 (1996).
Myers, M. G. Jr & Olson, D. P. Nature 491, 357–363 (2012).
Author information
Authors and Affiliations
Corresponding authors
Related links
Rights and permissions
About this article
Cite this article
Ruud, J., Brüning, J. Light on leptin link to lipolysis. Nature 527, 43–44 (2015). https://doi.org/10.1038/527043a
Published:
Issue Date:
DOI: https://doi.org/10.1038/527043a
- Springer Nature Limited
This article is cited by
-
Cancer-cell-secreted miR-204-5p induces leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia
Nature Communications (2023)
-
CD8+ T cells induce cachexia during chronic viral infection
Nature Immunology (2019)