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Organic chemistry

Natural polarity inverted

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The concept of umpolung describes the reversal of the naturally occurring electrostatic polarization of chemical groups. It has now been used to make single mirror-image isomers of nitrogen-containing molecules. See Letter p.445

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Figure 1: Umpolung for ketones and imines.
Figure 2: Catalytic enantioselective reactions of umpolung imines.

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Authors and Affiliations

  1. Fedor Romanov-Michailidis and Tomislav Rovis are in the Chemistry Department, Colorado State University, Fort Collins, Colorado 80523, USA.,

    Fedor Romanov-Michailidis & Tomislav Rovis

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  1. Fedor Romanov-Michailidis
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  2. Tomislav Rovis
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Correspondence to Tomislav Rovis.

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Romanov-Michailidis, F., Rovis, T. Natural polarity inverted. Nature 523, 417–418 (2015). https://doi.org/10.1038/523417a

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