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Cell metabolism

Sugar for sight

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Retinitis pigmentosa causes the death of cone cells, leading to blindness. A factor secreted from rod cells, RdCVF, promotes cone survival in a mouse model of the disease. It now emerges that RdCVF works by increasing glucose uptake in cones.

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Figure 1: Glucose uptake in cone cells.

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References

  1. https://sph.uth.edu/retnet

  2. Hartong, D. T., Berson, E. L. & Dryja, T. P. Lancet 368, 1795–1809 (2006).

    Article  CAS  Google Scholar 

  3. Aït-Ali, N. et al. Cell 161, 817–832 (2015).

    Article  Google Scholar 

  4. Komeima, K., Rogers, B. S., Lu, L. & Campochiaro, P. A. Proc. Natl Acad. Sci. USA 103, 11300–11305 (2006).

    Article  CAS  ADS  Google Scholar 

  5. Yu, D.-Y., Cringle, S. J., Su, E.-N. & Yu, P. K. Invest. Ophthalmol. Vis. Sci. 41, 3999–4006 (2000).

    CAS  PubMed  Google Scholar 

  6. Xiong, W., MacColl Garfinkel, A. E., Li, Y., Benowitz, L. I. & Cepko, C. L. J. Clin. Invest. 125, 1433–1445 (2015).

    Article  Google Scholar 

  7. Punzo, C., Kornacker, K. & Cepko, C. L. Nature Neurosci. 12, 44–52 (2009).

    Article  CAS  Google Scholar 

  8. Venkatesh, A. et al. J. Clin. Invest. 125, 1446–1458 (2015).

    Article  Google Scholar 

  9. Graymore, C. Br. J. Ophthalmol. 43, 34–39 (1959).

    Article  CAS  Google Scholar 

  10. Léveillard, T. S. et al. Nature Genet. 36, 755–759 (2004).

    Article  Google Scholar 

  11. Holmgren, A. Annu. Rev. Biochem. 54, 237–271 (1985).

    Article  CAS  Google Scholar 

  12. Cronin, T. et al. Cell Death Differ. 17, 1199–1210 (2010).

    Article  CAS  Google Scholar 

  13. Hori, K. et al. Invest. Ophthalmol. Vis. Sci. 41, 3128–3133 (2000).

    CAS  PubMed  Google Scholar 

  14. Philp, N. J., Ochrietor, J. D., Rudoy, C., Muramatsu, T. & Linser, P. J. Invest. Ophthalmol. Vis. Sci. 44, 1305–1311 (2003).

    Article  Google Scholar 

  15. Byrne, L. C. et al. J. Clin. Invest. 125, 105–116 (2015).

    Article  Google Scholar 

  16. Trapani, I., Banfi, S., Simonelli, F., Surace, E. M. & Auricchio, A. Hum. Gene Ther. 26, 193–200 (2015).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Connie Cepko is in the Departments of Genetics and of Ophthalmology, and at the Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.,

    Connie Cepko

  2. Claudio Punzo is in the Department of Ophthalmology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.,

    Claudio Punzo

Authors
  1. Connie Cepko
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  2. Claudio Punzo
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Correspondence to Connie Cepko or Claudio Punzo.

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Cepko, C., Punzo, C. Sugar for sight. Nature 522, 428–429 (2015). https://doi.org/10.1038/522428a

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