Skip to main content
Log in

Stem cells

A designer's guide to pluripotency

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

Pluripotent stem cells, which give rise to almost all cell types, can be engineered from mature cells. A thorough analysis of the process has led to the characterization of a new type of pluripotent cell. See Articles p.192 & p.198

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Different flavours of pluripotency.

References

  1. Evans, M. J. & Kaufman, M. H. Nature 292, 154–156 (1981).

    ADS  CAS  Google Scholar 

  2. Martin, G. R. Proc. Natl Acad. Sci. USA 78, 7634–7638 (1981).

    Article  ADS  CAS  Google Scholar 

  3. Brons, I. G. et al. Nature 448, 191–195 (2007).

    Article  ADS  CAS  Google Scholar 

  4. Tesar, P. J. et al. Nature 448, 196–199 (2007).

    Article  ADS  CAS  Google Scholar 

  5. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  Google Scholar 

  6. Shu, J. et al. Cell 153, 963–975 (2013).

    Article  CAS  Google Scholar 

  7. Montserrat, N. et al. Cell Stem Cell 13, 351–350 (2013).

    Article  Google Scholar 

  8. Han, D. W. et al. Nature Cell Biol. 13, 66–71 (2010).

    Article  Google Scholar 

  9. Tonge, P. D. et al. Nature 516, 192–197 (2014).

    Article  ADS  CAS  Google Scholar 

  10. Hussein, S. M. I. et al. Nature 516, 198–206 (2014).

    Article  ADS  CAS  Google Scholar 

  11. Lee, D. S. et al. Nature Commun. 5, 5619; http://dx.doi.org/10.1038/ncomms6619 (2014).

    Article  ADS  CAS  Google Scholar 

  12. Clancy, J. L. et al. Nature Commun. 5, 5522; http://dx.doi.org/10.1038/ncomms6522 (2014).

  13. Benevento, M. et al. Nature Commun. 5, 5613; http://dx.doi.org/10.1038/ncomms6613 (2014).

    Article  ADS  CAS  Google Scholar 

  14. Woltjen, K. et al. Nature 458, 766–770 (2009).

    Article  ADS  CAS  Google Scholar 

  15. Pagliuca, F. W. et al. Cell 159, 428–438 (2014).

    Article  CAS  Google Scholar 

  16. Gafni, O. et al. Nature 504, 282–286 (2013).

    Article  ADS  CAS  Google Scholar 

  17. Theunissen, T. W. et al. Cell Stem Cell 15, 471–487 (2014).

    Article  CAS  Google Scholar 

  18. Zhou, W. et al. EMBO J. 31, 2103–2116 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Juan Carlos Izpisua Belmonte.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wu, J., Belmonte, J. A designer's guide to pluripotency. Nature 516, 172–173 (2014). https://doi.org/10.1038/516172a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/516172a

  • Springer Nature Limited

This article is cited by

Navigation