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Depression

The best way forward

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Conventional behavioural mouse models of depression are often used to study the disorder, but cannot capture the full picture of the human disease. Here, scientists present two views about the best research strategies to adopt if treatments are to be improved.

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Figure 1: Approaches to drug discovery for depression.

References

  1. Li, B. et al. Nature 470, 535–539 (2011).

    Article  ADS  CAS  Google Scholar 

  2. Nestler, E. J. & Hyman, S. E. Nature Neurosci. 13, 1161–1169 (2010).

    Article  CAS  Google Scholar 

  3. Berman, R. M. et al. Biol. Psychiatry 47, 351–354 (2000).

    Article  CAS  Google Scholar 

  4. Price, R. B., Nock, M. K., Charney, D. S. & Mathew, S. J. Biol. Psychiatry 66, 522–526 (2009).

    Article  CAS  Google Scholar 

  5. Autry, A. E. et al. Nature 475, 91–95 (2011).

    Article  CAS  Google Scholar 

  6. Kavalali, E. T. & Monteggia, L. M. Am. J. Psychiatry 169, 1150–1156 (2012).

    Article  Google Scholar 

  7. Hyman, S. E. Neuropsychopharmacology 39, 220–229 (2014).

    Article  CAS  Google Scholar 

  8. Moghaddam, B. & Krystal, J. H. Schizophrenia Bull. 38, 942–949 (2012).

    Article  Google Scholar 

  9. Deisseroth, K. Nature 505, 309–317 (2014).

    Article  ADS  CAS  Google Scholar 

  10. Steinberg, E. E., Christoffel, D. J., Deisseroth, K. & Malenka, R. C. Curr. Opin. Neurobiol. 30, 9–16 (2015).

    Article  CAS  Google Scholar 

  11. Akil, H. et al. Science 327, 1580–1581 (2010).

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Lisa M. Monteggia is in the Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111, USA.,

    Lisa M. Monteggia

  2. Robert C. Malenka and Karl Deisseroth are in the Departments of Psychiatry and Behavioral Sciences and of Bioengineering, Stanford University, Stanford, California 94305, USA.,

    Robert C. Malenka & Karl Deisseroth

Authors
  1. Lisa M. Monteggia
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  2. Robert C. Malenka
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  3. Karl Deisseroth
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Corresponding authors

Correspondence to Lisa M. Monteggia or Robert C. Malenka.

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Monteggia, L., Malenka, R. & Deisseroth, K. The best way forward. Nature 515, 200–201 (2014). https://doi.org/10.1038/515200a

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