The finding that RIPK1, an integral protein in cell-death pathways, also functions to preserve the body's epithelial-cell barriers challenges the idea that cell death and survival are regulated by distinct factors. See Letters p.90 & p.95
References
Dannappel, M. et al. Nature 513, 90–94 (2014).
Takahashi, N. et al. Nature 513, 95–99 (2014).
Stanger, B. Z., Leder, P., Lee, T.-H., Kim, E. & Seed, B. Cell 81, 513–523 (1995).
Rickard, J. A. et al. Cell 157, 1175–1188 (2014).
Dillon, C. P. et al. Cell 157, 1189–1202 (2014).
Kaiser, W. J. et al. Proc. Natl Acad. Sci. USA 111, 7753–7758 (2014).
Edinger, A. L. & Thompson, C. B. Curr. Opin. Cell Biol. 16, 663–669 (2004).
Moriwaki, K. & Chan, F. K.-M. Genes Dev. 27, 1640–1649 (2013).
Kelliher, M. A. et al. Immunity 9, 297–303 (1998).
Ting, A. T., Pimentel-Muiños, F. X. & Seed, B. EMBO J. 15, 6189–6196 (1996).
Chan, F. K.-M. et al. J. Biol. Chem. 278, 51613–51621 (2003).
Wang, L., Du, F. & Wang, X. Cell 133, 693–703 (2008).
Hooper, L. V., Littman, D. R. & Macpherson, A. J. Science 336, 1268–1273 (2012).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Chan, FM. A guardian angel of cell integrity. Nature 513, 38–39 (2014). https://doi.org/10.1038/513038a
Published:
Issue Date:
DOI: https://doi.org/10.1038/513038a
- Springer Nature Limited