One aim of synthetic biology is to generate complex synthetic organisms. Now, a stage in this process has been achieved in yeast cells — an entire yeast chromosome has been converted to a synthetic sequence in a stepwise manner.
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Gibson, D., Venter, J. Construction of a yeast chromosome. Nature 509, 168–169 (2014). https://doi.org/10.1038/509168a
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DOI: https://doi.org/10.1038/509168a
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