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Programming genomes with light

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The combination of two techniques — optogenetics and genome editing using engineered nucleases — now provides a general means for the light-controlled regulation of any gene of interest. See Letter p.472

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Figure 1: Modular control of genome function.

References

  1. Konermann, S. et al. Nature 500, 472–476 (2013).

    Article  CAS  ADS  Google Scholar 

  2. Yizhar, O., Fenno, L. E., Davidson, T. J., Mogri, M. & Deisseroth, K. Neuron 71, 9–34 (2011).

    Article  CAS  Google Scholar 

  3. Moffat, K., Zhang, F., Hahn, K. M. & Möglich, A. in Optogenetics (eds Hegemann, P. & Sigrist, S.) 7–22 (Walter de Gruyter, 2013).

    Google Scholar 

  4. Kennedy, M. J. et al. Nature Meth. 7, 973–975 (2010).

    Article  CAS  Google Scholar 

  5. Shimizu-Sato, S., Huq, E., Tepperman, J. M. & Quail, P. H. Nature Biotechnol. 20, 1041–1044 (2002).

    Article  CAS  Google Scholar 

  6. Wang, X., Chen, X. & Yang, Y. Nature Meth. 9, 266–269 (2012).

    Article  CAS  Google Scholar 

  7. Polstein, L. R. & Gersbach, C. A. J. Am. Chem. Soc. 134, 16480–16483 (2012).

    Article  CAS  Google Scholar 

  8. Müller, K. et al. Nucleic Acids Res. 41, e124 (2013).

    Article  ADS  Google Scholar 

  9. Boch, J. et al. Science 326, 1509–1512 (2009).

    Article  CAS  ADS  Google Scholar 

  10. Charpentier, E. & Doudna, J. A. Nature 495, 50–51 (2013).

    Article  CAS  ADS  Google Scholar 

  11. Gilbert, L. A. et al. Cell 154, 442–451 (2013).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Andreas Möglich is in the Department of Biophysical Chemistry at the Institute of Biology, Humboldt-Universität zu Berlin, 10115 Berlin, Germany.,

    Andreas Möglich

  2. Peter Hegemann is in the Department of Experimental Biophysics at the Humboldt-Universität zu Berlin.,

    Peter Hegemann

Authors
  1. Andreas Möglich
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  2. Peter Hegemann
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Correspondence to Andreas Möglich or Peter Hegemann.

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Möglich, A., Hegemann, P. Programming genomes with light. Nature 500, 406–408 (2013). https://doi.org/10.1038/500406a

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