Skip to main content
SpringerLink
Log in

Cell signalling

Nutrient sensing lost in cancer

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

Cells can sense and respond to fluctuations in nutrient availability. Mutations that disrupt such lines of nutrient communication with the cellular growth machinery seem to contribute to the uncontrolled growth of cancer cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Nutrient sensing and mTORC1.

References

  1. Bar-Peled, L. et al. Science 340, 1100–1106 (2013).

    Article  ADS  CAS  Google Scholar 

  2. Laplante, M. & Sabatini, D. M. Cell 149, 274–293 (2012).

    Article  CAS  Google Scholar 

  3. Dibble, C. C. & Manning, B. D. Nature Cell Biol. 15, 555–564 (2013).

    Article  CAS  Google Scholar 

  4. Neklesa, T. K. & Davis, R. W. PLoS Genet. 5, e1000515 (2009).

    Article  Google Scholar 

  5. Panchaud, N., Péli-Gulli, M. P. & De Virgilio, C. Sci. Signal. 6, ra42 (2013).

    Article  Google Scholar 

  6. Menon, S. & Manning, B. D. Oncogene 27, S43–S51 (2008).

    Article  CAS  Google Scholar 

  7. Li, J. et al. Cancer Res. 64, 6438 (2004).

    Article  CAS  Google Scholar 

  8. Leprivier, G. et al. Cell 153, 1064–1079 (2013).

    Article  CAS  Google Scholar 

  9. Shackelford, D. B. et al. Cancer Cell 23, 143–158 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Suchithra Menon and Brendan D. Manning are in the Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.,

    Suchithra Menon & Brendan D. Manning

Authors
  1. Suchithra Menon
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Brendan D. Manning
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Brendan D. Manning.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Menon, S., Manning, B. Nutrient sensing lost in cancer. Nature 498, 444–445 (2013). https://doi.org/10.1038/498444a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/498444a

  • Springer Nature Limited

This article is cited by

Search

Navigation