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The inner life of proteins

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A quantitative analysis shows that epistasis — the fact that genetic background determines whether a mutation is beneficial, deleterious or inconsequential — is the main factor regulating evolution at the level of proteins. See Letter p.535

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References

  1. Breen, M. S., Kemena, C., Vlasov, P. K., Notredame, C. & Kondrashov, F. A. Nature 490, 535–538 (2012).

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  2. Templeton, A. R. in Epistasis and the Evolutionary Process (eds Wolf, J. B., Brodie, E. D. III & Wade, M. J.) 41–57 (Oxford Univ. Press, 2000).

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  3. Fisher, R. A. The Genetical Theory of Natural Selection (Clarendon, 1930).

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Authors and Affiliations

  1. Günter P. Wagner is in the Department of Ecology and Evolutionary Biology, and at the Yale Systems Biology Institute, Yale University, New Haven, Connecticut 06477, USA.,

    Günter P. Wagner

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  1. Günter P. Wagner
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Correspondence to Günter P. Wagner.

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Wagner, G. The inner life of proteins. Nature 490, 493–494 (2012). https://doi.org/10.1038/490493a

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