In multiple sclerosis, the body's own immune cells attack the brain and spinal cord. But how they get there from peripheral tissues has been a mystery. Surprisingly, the lungs might be a key transit point. See Letter p.675
References
Odoardi, F. et al. Nature 488, 675–679 (2012).
Kojima, K. et al. J. Exp. Med. 180, 817–829 (1994).
Flügel, A. et al. Immunity 14, 547–560 (2001).
Bartholomäus, I. et al. Nature 462, 94–98 (2009).
Denk, W., Strickler, J. H. & Webb, W. W. Science 248, 73–76 (1990).
Laudanna, C. & Constantin, G. J. Immunol. Methods 273, 115–123 (2003).
Johnston, B. et al. J. Immunol. 164, 3337–3344 (2000).
Ransohoff, R. M. Nature 462, 41–42 (2009).
Purwar, R. et al. PLoS ONE 6, e16245 (2011).
Moyron-Quiroz, J. E. et al. Nature Med. 10, 927–934 (2004).
Richmond, I. et al. Thorax 48, 1130–1134 (1993).
van der Mei, I. A. et al. Neurol. Clin. 29, 233–255 (2011).
Sibley, W. A., Bamford, C. R. & Clark, K. Lancet 1, 1313–1315 (1985).
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Ransohoff, R. Licensed in the lungs. Nature 488, 595–596 (2012). https://doi.org/10.1038/488595a
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DOI: https://doi.org/10.1038/488595a
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