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Cancer

Exploiting collateral damage

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Some mutations in tumour cells play no part in causing cancer, but they generate cellular weak spots that may allow tumour cells to be selectively killed by drugs. See Article p.337

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Figure 1: Therapy in the passenger seat.

References

  1. Muller, F. L. et al. Nature 488, 337–342 (2012).

    Article  CAS  ADS  Google Scholar 

  2. Sellers, W. R. Cell 147, 26–31 (2011).

    Article  CAS  Google Scholar 

  3. Workman, P. & de Bono, J. Curr. Opin. Pharmacol. 8, 359–362 (2008).

    Article  CAS  Google Scholar 

  4. Stratton, M. R., Campbell, P. J. & Futreal, P. A. Nature 458, 719–724 (2009).

    Article  CAS  ADS  Google Scholar 

  5. Vavouri, T., Semple, J. I. & Lehner, B. Trends Genet. 24, 485–488 (2008).

    Article  CAS  Google Scholar 

  6. Kafri, R., Bar-Even, A. & Pilpel, Y. Nature Genet. 37, 295–299 (2005).

    Article  CAS  Google Scholar 

  7. Burga, A., Casanueva, M. O. & Lehner, B. Nature 480, 250–253 (2011).

    Article  CAS  ADS  Google Scholar 

  8. Lehner, B. Trends Genet. 27, 323–331 (2011).

    Article  CAS  Google Scholar 

  9. Hartwell, L. H., Szankasi, P., Roberts, C. J., Murray, A. W. & Friend, S. H. Science 278, 1064–1068 (1997).

    Article  CAS  ADS  Google Scholar 

  10. Chan, D. A. & Giaccia, A. J. Nature Rev. Drug Discov. 10, 351–364 (2011).

    Article  CAS  Google Scholar 

  11. Nijhawan, D. et al. Cell http://dx.doi.org/10.1016/j.cell.2012.07.023 (2012).

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Authors and Affiliations

  1. Ben Lehner and Solip Park are in the EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation, Universitat Pompeu Fabra, 08003 Barcelona, Spain.,

    Ben Lehner & Solip Park

  2. B. L. is also at the Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona.,

    Ben Lehner

Authors
  1. Ben Lehner
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  2. Solip Park
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Correspondence to Ben Lehner.

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Lehner, B., Park, S. Exploiting collateral damage. Nature 488, 284–285 (2012). https://doi.org/10.1038/488284a

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