The search for safe, non-addictive versions of morphine and other opioid drugs has just received a boost with the solving of the crystal structures of the receptors to which the drugs bind. See Articles p.321 & p.327, Letters p.395 & p.400
This is a preview of subscription content, log in via an institution to check access.
References
Results from the 2009 National Survey on Drug Use and Health: Volume I. Summary of National Findings (Office of Applied Studies, Rockville, MD, 2010).
Thompson, A. A. et al. Nature 485, 395–399 (2012).
Wu, H. et al. Nature 485, 327–332 (2012).
Manglik, A. et al. Nature 485, 321–326 (2012).
Granier, S. et al. Nature 485, 400–404 (2012).
Rosenbaum, D. M. et al. Science 318, 1266–1273 (2007).
Cherezov, V., Abola, E. & Stevens, R. C. Meth. Mol.Biol. 654, 141–168 (2010).
Wu, B. et al. Science 330, 1066–1071 (2010).
Warne, T. et al. Nature 454, 486–491 (2008).
Moukhametzianov, R. et al. Proc. Natl Acad. Sci. USA 108, 8228–8232 (2011).
Molinari, P. et al. J. Biol. Chem. 285, 12522–12535 (2010).
Rozenfeld, R. & Devi, L. A. Trends Pharmacol Sci. 31, 124–130 (2010).
van Rijn, R. M., Whistler, J. L. & Waldhoer, M. Curr. Opin. Pharmacol. 10, 73–79 (2010).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Filizola, M., Devi, L. How opioid drugs bind to receptors. Nature 485, 314–317 (2012). https://doi.org/10.1038/485314a
Published:
Issue Date:
DOI: https://doi.org/10.1038/485314a
- Springer Nature Limited
This article is cited by
-
Computational insights into the subtype selectivity and “message-address-efficacy” mechanisms of opioid receptors through JDTic binding and unbinding
Acta Pharmacologica Sinica (2018)
-
Computational insights into the G-protein-biased activation and inactivation mechanisms of the μ opioid receptor
Acta Pharmacologica Sinica (2018)
-
“In silico” study of the binding of two novel antagonists to the nociceptin receptor
Journal of Computer-Aided Molecular Design (2018)
-
Molecular switches of the κ opioid receptor triggered by 6′-GNTI and 5′-GNTI
Scientific Reports (2016)
-
An antioxidant mechanism of morphine and related derivatives
Medicinal Chemistry Research (2016)