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Clinical trials unite mice and humans

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Anticancer 'co-clinical' trials, in which mice carrying known mutations are treated in parallel with patients enrolled in a simultaneous clinical study, could help to improve therapeutic outcome. See Letter p.613

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References

  1. Chen, Z. et al. Nature 483, 613–617 (2012).

    Article  CAS  ADS  Google Scholar 

  2. Douillard, J. Y. et al. J. Clin. Oncol. 28, 744–752 (2010).

    Article  CAS  Google Scholar 

  3. Mascaux, C. et al. Br. J. Cancer 92, 131–139 (2005).

    Article  CAS  Google Scholar 

  4. Ji, H. et al. Cancer Res. 67, 4933–4939 (2007).

    Article  CAS  Google Scholar 

  5. Hoeflich, K. P. et al. Cancer Res. 72, 210–219 (2012).

    Article  CAS  Google Scholar 

  6. Jackson, E. L. et al. Cancer Res. 65, 10280–10288 (2005).

    Article  CAS  Google Scholar 

  7. Singh, M. et al. Nature Biotechnol. 28, 585–593 (2010).

    Article  CAS  Google Scholar 

  8. Ji, H. et al. Nature 448, 807–810 (2007).

    Article  CAS  ADS  Google Scholar 

  9. Berghmans, T. et al. Thorac. Oncol. 3, 6–12 (2008).

    Article  Google Scholar 

  10. Erasmus, J. J., Rohren, E. & Swisher, S. G. Proc. Am. Thorac. Soc. 6, 171–179 (2009).

    Article  Google Scholar 

  11. Kola, I. & Landis, J. Nature Rev. Drug Discov. 3, 711–716 (2004).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Leisa Johnson.

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The author is an employee of Genentech, a member of the Roche Group. She owns restricted stock units and stock options in Roche. Genentech/Roche owns all patent rights for which employees are listed as an inventor or co-inventor.

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Johnson, L. Clinical trials unite mice and humans. Nature 483, 547–548 (2012). https://doi.org/10.1038/483546a

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