Skip to main content
SpringerLink
Log in

Organic chemistry

Stabilizers cause instability

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

Any chemist will tell you that amide compounds are renowned for their stability, yet a family of amides has been discovered that is surprisingly unstable. The cause of this phenomenon is even more surprising.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Amide reactivity.

References

  1. Hutchby, M. et al. Angew. Chem. Int. Edn 51, 548–551 (2012).

    Article  CAS  Google Scholar 

  2. Snieckus, V. Chem. Rev. 90, 879–933 (1990).

    Article  CAS  Google Scholar 

  3. Clayden, J., Foricher, Y. J. Y. & Lam, H. K. Chem. Commun. 2138–2139 (2002).

  4. Clayden, J., Foricher, Y. J. Y. & Lam, H. K. Eur. J. Org. Chem. 3558–3565 (2002).

  5. Clayden, J. & Moran, W. J. Angew. Chem. Int. Edn 45, 7118–7120 (2006).

    Article  CAS  Google Scholar 

  6. Szostak, M. & Aubé, J. Org. Biomol. Chem. 9, 27–35 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Jonathan Clayden is in the School of Chemistry, University of Manchester, Manchester M13 9PL, UK.,

    Jonathan Clayden

Authors
  1. Jonathan Clayden
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jonathan Clayden.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Clayden, J. Stabilizers cause instability. Nature 481, 274–275 (2012). https://doi.org/10.1038/481274a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/481274a

  • Springer Nature Limited

Search

Navigation