Skip to main content
Log in

Biophysics

More than a bystander

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

The tendency of hydrophobic surfaces to aggregate in water is often invoked to explain how biomolecules recognize and bind to each other. Water seems to have a much more active role in these processes than had been thought.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Water motion in enzyme–substrate binding.

References

  1. Li, I. T. S. & Walker, G. C. Proc. Natl Acad. Sci. USA 108, 16527–16532 (2011).

    Article  ADS  CAS  Google Scholar 

  2. Snyder, P. W. et al. Proc. Natl Acad. Sci. USA http://dx.doi.org/10.1073/pnas.1114107108 (2011).

  3. Grossman, M. et al. Nature Struct. Mol. Biol. 18, 1102–1108 (2011).

    Article  CAS  Google Scholar 

  4. Tanford, C. The Hydrophobic Effect 2nd edn (Wiley, 1980).

    Google Scholar 

  5. Southall, N. T., Dill, K. A. & Hayment, A. D. J. J. Phys. Chem. B 106, 521–533 (2002).

    Article  CAS  Google Scholar 

  6. Kauzmann, W. Adv. Protein Chem. 14, 1–63 (1959).

    Article  CAS  Google Scholar 

  7. Blokzijl, W. & Engberts, J. B. F. N. Angew. Chem. Int. Edn 32, 1545–1579 (1993).

    Article  Google Scholar 

  8. Lum, K., Chandler, D. & Weeks, J. D. J. Phys. Chem. B 103, 4570–4577 (1999).

    Article  CAS  Google Scholar 

  9. Zhou, R., Huang, X., Margulis, C. J. & Berne, B. J. Science 305, 1605–1609 (2004).

    Article  ADS  CAS  Google Scholar 

  10. Wang, J., Kudesia, S., Bratko, D. & Luzar, A. Phys. Chem. Chem. Phys. http://dx.doi.org/10.1039/c1cp22082a (2011).

  11. Liu, P., Huang, X., Zhou, R. & Berne, B. J. Nature 437, 159–162 (2005).

    Article  ADS  CAS  Google Scholar 

  12. Huang, D. M. & Chandler, D. J. Phys. Chem. B 106, 2047–2053 (2002).

    Article  CAS  Google Scholar 

  13. Willard, A. P. & Chandler D . J. Phys. Chem. B 112, 6187–6192 (2008).

    Article  CAS  Google Scholar 

  14. Patel, A. J. et al. preprint at http://arxiv.org/abs/1109.4431 (2011).

  15. Mora, T. & Bialek, W. J. Stat. Phys. 144, 268–302 (2011).

    Article  ADS  MathSciNet  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ball, P. More than a bystander. Nature 478, 467–468 (2011). https://doi.org/10.1038/478467a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/478467a

  • Springer Nature Limited

This article is cited by

Navigation