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Snapshot of a signalling complex

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G-protein-coupled receptors initiate signalling pathways by forming complexes with agonist molecules and G proteins. The first crystal structure of such a complex is both reassuring and provocative. See Article p.549 & Letter p.611

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Figure 1: Activated receptor–G-protein complex.

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Authors and Affiliations

  1. Department of Neuroscience and Pharmacology, Thue W. Schwartz is in the Laboratory for Molecular Pharmacology, and at the NNF Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.,

    Thue W. Schwartz

  2. Thomas P. Sakmar is in the Laboratory of Molecular Biology and Biochemistry, The Rockefeller University, New York 10065, USA.,

    Thomas P. Sakmar

Authors
  1. Thue W. Schwartz
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  2. Thomas P. Sakmar
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Correspondence to Thue W. Schwartz or Thomas P. Sakmar.

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Schwartz, T., Sakmar, T. Snapshot of a signalling complex. Nature 477, 540–541 (2011). https://doi.org/10.1038/477540a

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