The synthesis of conolidine, a scarce, naturally occurring compound, has enabled the first studies of its pharmacological properties to be carried out. Excitingly, conolidine is a painkiller that seems to have an unusual mechanism of action.
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References
Tarselli, M. A. et al. Nature Chem. 3, 449–453 (2011).
Kam, T.-S., Pang, H.-S., Choo, Y.-M. & Komiyama, K. Chem. Biodiver. 1, 646–656 (2004).
Potier, P. & Janot, M. M. C.R. Acad. Sci. 276C, 1727 (1973).
Scott, A. I., Yeh, C.-L. & Greenslade, D. J. Chem. Soc. Chem. Commun. 947–948 (1978).
Rice, K. C. in The Chemistry and Biology of Isoquinoline Alkaloids (eds Phillipson, J. D., Roberts, M. F. & Zenk, M. H.) 191–203 (Springer, 1985).
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Reisman, S. New lead for pain treatment. Nature 473, 458–459 (2011). https://doi.org/10.1038/473458a
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DOI: https://doi.org/10.1038/473458a
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