The TH17 helper cells of the immune system have a dark side: they mediate autoimmune disorders. Two drugs that prevent the differentiation and activity of these cells might be of therapeutic value. See Letters p.486 & p.491
References
Huh, J. R. et al. Nature 472, 486–490 (2011).
Solt, L. A. et al. Nature 472, 491–494 (2011).
Ivanov, I. I. et al. Cell 126, 1121–1133 (2006).
Jetten, A. M. Nucl. Recept. Signal. 7, e003 (2009).
Yang, X. O. et al. Immunity 28, 29–39 (2008).
Kumar, N. et al. Mol. Pharmacol. 77, 228–236 (2010).
O'Connor, W. Jr, Zenewicz, L. A. & Flavell, R. A. Nature Immunol. 11, 471–476 (2010).
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Jetten, A. A helping hand against autoimmunity. Nature 472, 421–422 (2011). https://doi.org/10.1038/472421a
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DOI: https://doi.org/10.1038/472421a
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