Twenty amino acids form the basis of all proteins, but another two genetically encoded amino acids have also been discovered. The biosynthesis of one of these, pyrrolysine, has now been elucidated. See Letter p.647
References
Hao, B. et al. Science 296, 1462–1466 (2002).
Srinivasan, G., James, C. M. & Krzycki, J. A. Science 296, 1459–1462 (2002).
Rother, M. & Krzycki, J. A. Archaea 2010, 453642 doi:10.1155/2010/453642 (2010).
Gaston, M. A., Zhang, L., Green-Church, K. B. & Krzycki, J. A. Nature 471, 647–650 (2011).
Longstaff, D. G. et al. Proc. Natl Acad. Sci. USA 104, 1021–1026 (2007).
Polycarpo, C. et al. Proc. Natl Acad. Sci. USA 101, 12450–12454 (2004).
Blight, S. K. et al. Nature 431, 333–335 (2004).
Namy, O. et al. FEBS Lett. 581, 5282–5288 (2007).
Krzycki, J. A. Curr. Opin. Chem. Biol. 8, 484–491 (2004).
Frey, P. A., Hegeman, A. D. & Ruzicka, F. J. Crit. Rev. Biochem. Mol. Biol. 43, 63–88 (2008).
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Ragsdale, S. How two amino acids become one. Nature 471, 583–584 (2011). https://doi.org/10.1038/471583a
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DOI: https://doi.org/10.1038/471583a
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