The vitamin-A metabolite retinoic acid normally favours immune tolerance in the gut. But in coeliac disease — an intestinal inflammatory disorder due to adverse reactivity to a dietary protein — it may do just the opposite. See Letter p.220
References
DePaolo, R. R. et al. Nature 271, 220–224 (2011).
Coombes, J. L. et al. J. Exp. Med. 204, 1757–1764 (2007).
Sun, C. M. et al. J. Exp. Med. 204, 1775–1785 (2007).
Mucida, D. et al. Science 317, 256–260 (2007).
Jabri, B. & Sollid, L. M. Nature Rev. Immunol. 9, 858–870 (2009).
Kagnoff, M. F. J. Clin. Invest. 117, 41–49 (2007).
Meresse, B., Ripoche, J., Heyman, M. & Cerf-Bensussan, N. Mucosal Immunol. 2, 8–23 (2009).
Reddy, D. et al. Am. J. Gastroenterol. 101, 1569–1573 (2006).
Hunt, K. A. et al. Nature Genet. 40, 395–402 (2008).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Maynard, C., Weaver, C. Context is key in the gut. Nature 471, 169–170 (2011). https://doi.org/10.1038/471169a
Published:
Issue Date:
DOI: https://doi.org/10.1038/471169a
- Springer Nature Limited