Skip to main content
Log in

Protein folding

Protection from the outside

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

Protein folding is a high-stakes process, with cell dysfunction and death being the unforgiving penalties for failure. Work in bacteria hints that organisms manage this process beyond the boundaries of the cytoplasm — and even the cell.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Powers, E. T., Morimoto, R. I., Dillin, A., Kelly, J. W. & Balch, W. E. Annu. Rev. Biochem. 78, 959–991 (2009).

    Article  CAS  Google Scholar 

  2. Balch, W. E., Morimoto, R. I., Dillin, A. & Kelly, J. W. Science 319, 916–919 (2008).

    Article  CAS  ADS  Google Scholar 

  3. Roth, D. M. & Balch, W. E. Curr. Opin. Cell Biol. doi:10.1016/j.ceb.2010.11.001 (2010).

  4. Quan, S. et al. Nature Struct. Mol. Biol. doi:10.1038/nsmb.2016 (2011).

  5. Capaldi, A. P., Kleanthous, C. & Radford, S. E. Nature Struct. Biol. 9, 209–216 (2002).

    CAS  PubMed  Google Scholar 

  6. Saibil, H. R. Curr. Opin. Struct. Biol. 18, 35–42 (2008).

    Article  CAS  Google Scholar 

  7. Street, T. O., Bolen, D. W. & Rose, G. D. Proc. Natl Acad. Sci. USA 103, 13997–14002 (2006).

    Article  CAS  ADS  Google Scholar 

  8. Pauwels, K., Van Molle, I., Tommassen, J. & Van Gelder, P. Mol. Microbiol. 64, 917–922 (2007).

    Article  CAS  Google Scholar 

  9. Allen, W. J., Phan, G. & Waksman, G. Adv. Protein Chem. Struct. Biol. 78, 51–97 (2009).

    Article  CAS  Google Scholar 

  10. Horváth, I., Multhoff, G., Sonnleitner, A. & Vigh, L. Biochim. Biophys. Acta 1778, 1653–1664 (2008).

    Article  Google Scholar 

  11. Zsila, F. Bioorg. Med. Chem. Lett. 20, 1205–1209 (2010).

    Article  CAS  Google Scholar 

  12. Zsila, F. Biochem. Biophys. Res. Commun. 393, 242–247 (2010).

    Article  CAS  Google Scholar 

  13. Bouchecareilh, M., Conkright, J. J. & Balch, W. E. Proc. Am. Thorac. Soc. 7, 415–422 (2010).

    Article  CAS  Google Scholar 

  14. Stockert, R. J. Physiol. Rev. 75, 591–609 (1995).

    Article  CAS  Google Scholar 

  15. Page, L. J. et al. Proc. Natl Acad. Sci. USA 106, 11125–11130 (2009).

    Article  CAS  ADS  Google Scholar 

  16. Wyatt, A., Yerbury, J., Poon, S., Dabbs, R. & Wilson, M. Adv. Cancer Res. 104, 89–114 (2009).

    Article  CAS  Google Scholar 

  17. Cray, C., Zaias, J. & Altman, N. H. Comp. Med. 59, 517–526 (2009).

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Buxbaum, J. N. & Reixach, N. Cell. Mol. Life Sci. 66, 3095–3101 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Evan T. Powers or William E. Balch.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Powers, E., Balch, W. Protection from the outside. Nature 471, 42–43 (2011). https://doi.org/10.1038/471042a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/471042a

  • Springer Nature Limited

This article is cited by

Navigation