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Flipping Watson and Crick

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Watson–Crick base pairs underpin the DNA double helix. Evidence of transient changes in base-pairing geometry highlights the fact that the information held in DNA's linear sequence is stored in three dimensions. See Article p.498

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Figure 1: Hoogsteen and Watson–Crick base pairing.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biophysics, Barry Honig is at the Howard Hughes Medical Institute, Center for Computational Biology and Bioinformatics, Columbia University, New York, New York 10032, USA.,

    Barry Honig

  2. Department of Biological Sciences, Remo Rohs is in the Molecular and Computational Biology Program, University of Southern California, Los Angeles, California 90089, USA.,

    Remo Rohs

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  1. Barry Honig
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  2. Remo Rohs
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Correspondence to Barry Honig or Remo Rohs.

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Honig, B., Rohs, R. Flipping Watson and Crick. Nature 470, 472–473 (2011). https://doi.org/10.1038/470472a

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