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Drug discovery

How melanomas bypass new therapy

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The promise of an exciting new drug that inhibits the mutant B-RAF protein in skin cancer is marred by the fact that most patients relapse within a year. Fresh data hint at how such resistance emerges. See Letters p.968 & p.973

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Figure 1: The short and long roads to PLX4032 resistance4,5.

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Solit, D., Sawyers, C. How melanomas bypass new therapy. Nature 468, 902–903 (2010). https://doi.org/10.1038/468902a

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