Scientists report the conversion of one type of differentiated cell, the fibroblast, into another — the cardiomyocyte. This approach may find use in regenerative strategies for the repair of damaged hearts.
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References
Ieda, M. et al. Cell 142, 375–386 (2010).
Gurdon, J. B. Annu. Rev. Cell Dev. Biol. 22, 1–22 (2006).
Campbell, K. H. S., McWhir, J., Ritchie, W. A. & Wilmut, I. Nature 380, 64–66 (1996).
Zhou, Q. & Melton, D. A. Cell Stem Cell 3, 382–388 (2008).
Weintraub, H. et al. Proc. Natl Acad. Sci. USA 86, 5434–5438 (1989).
Gehring, W. J. & Ikeo, K. Trends Genet. 15, 371–377 (1999).
Vierbuchen, T. et al. Nature 463, 1035–1041 (2010).
Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J. & Melton, D. A. Nature 455, 627–632 (2008).
Forsberg, M. et al. Proc. Natl Acad. Sci. USA doi:10.1073/pnas.1009412107 (2010).
Yamanaka, S. & Blau, H. M. Nature 465, 704–712 (2010).
Takeuchi, J. K. & Bruneau, B. G. Nature 459, 708–711 (2009).
Samavarchi-Tehrani, P. et al. Cell Stem Cell 7, 64–77 (2010).
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Harvey, R. Heart redevelopment. Nature 467, 39–40 (2010). https://doi.org/10.1038/467039a
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DOI: https://doi.org/10.1038/467039a
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