Presenilin proteins have a major role in normal cellular processes, but some contribute to disease, for example through the formation of amyloid-β. The way in which these different roles are regulated is now becoming clearer.
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References
He, G. et al. Nature 467, 95–98 (2010).
Sherrington, R. et al. Nature 375, 754–760 (1995).
Rogaev, E. I. et al. Nature 376, 775–778 (1995).
Francis, R. et al. Dev. Cell 3, 85–97 (2002).
Yu, G. et al. Nature 407, 48–54 (2000).
Takami, M. et al. J. Neurosci. 29, 13042–13052 (2009).
Chen, F. et al. Nature Cell Biol. 3, 751–754 (2001).
Netzer, W. J. et al. Proc. Natl Acad. Sci. USA 100, 12444–12449 (2003).
Chen, F. et al. Nature 440, 1208–1212 (2006).
Zhou, S., Zhou, H., Walian, P. J. & Jap, B. K. Proc. Natl Acad. Sci. USA 102, 7499–7504 (2005).
Thathiah, A. et al. Science 323, 946–951 (2009).
Munter, L. M. et al. EMBO J. 26, 1702–1712 (2007).
Pardossi-Piquard, R. et al. J. Biol. Chem. 284, 28634–28641 (2009).
Kukar, T. L. et al. Nature 453, 925–929 (2008).
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St George-Hyslop, P., Schmitt-Ulms, G. Selectively tuning γ-secretase. Nature 467, 36–37 (2010). https://doi.org/10.1038/467036a
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DOI: https://doi.org/10.1038/467036a
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