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Q&A: Cancer

Clues from cell metabolism

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Interest in the abnormal metabolism exhibited by cancer cells has been reawakened by the discovery of oncogenic mutations in metabolic enzymes, and by tools that monitor metabolism in living cells. Existing and emerging therapies aim to target this abnormal metabolism in various ways.

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Figure 1: Biochemistry of cancer-cell metabolism.
Figure 2: Regulation of HIF function.

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Authors and Affiliations

  1. William G. Kaelin Jr is at the Howard Hughes Medical Institute, and at the Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. william_kaelin@dfci.harvard.edu; ,

    William G. Kaelin Jr

  2. Craig B. Thompson is at the Abramson Cancer Center and Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. craig@exchange.upenn.edu ,

    Craig B. Thompson

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  1. William G. Kaelin Jr
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  2. Craig B. Thompson
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Competing interests

W.G.K. is a consultant to FibroGen Pharmaceuticals and to Agios Pharmaceuticals. C.B.T. is a founder and chair of the advisory board of Agios Pharmaceuticals.

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Kaelin, W., Thompson, C. Clues from cell metabolism. Nature 465, 562–564 (2010). https://doi.org/10.1038/465562a

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