Skip to main content
SpringerLink
Log in

Structural biology

Piston drives a proton pump

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

The membrane-spanning enzyme known as complex I couples the movement of electrons to that of protons as a way of converting energy. Crystal structures suggest how electron transfer drives proton pumping from afar.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Indirect coupling of electron transfer to proton pumping in complex I.

References

  1. Efremov, R. G., Baradaran, R. & Sazanov, L. A. Nature 465, 441–445 (2010).

    Article  ADS  CAS  Google Scholar 

  2. Mitchell, P. Science 206, 1148–1159 (1979).

    Article  ADS  CAS  Google Scholar 

  3. Carroll, J., Fearnley, I. M., Shannon, R. J., Hirst, J. & Walker, J. E. Mol. Cell. Proteomics 2, 117–126 (2003).

    Article  CAS  Google Scholar 

  4. Yagi, T., Yano, T., Di Bernardo, S. & Matsuno-Yagi, A. Biochim. Biophys. Acta 1364, 125–133 (1998).

    Article  CAS  Google Scholar 

  5. Ohnishi, T. Biochim. Biophys. Acta 1364, 186–206 (1998).

    Article  CAS  Google Scholar 

  6. Ohnishi, T. & Salerno, J. C. FEBS Lett. 579, 4555–4561 (2005).

    Article  CAS  Google Scholar 

  7. Hofhaus, G., Weiss, H. & Leonard, K. J. Mol. Biol. 221, 1027–1043 (1991).

    Article  CAS  Google Scholar 

  8. Sazanov, L. A. & Hinchliffe, P. Science 311, 1430–1436 (2006).

    Article  ADS  CAS  Google Scholar 

  9. Shinzawa-Itoh, K. et al. Biochemistry 49, 487–492 (2010).

    Article  CAS  Google Scholar 

  10. Wikström, M. FEBS Lett. 169, 300–304 (1984).

    Article  Google Scholar 

  11. Galkin, A. S., Grivennikova, V. G. & Vinogradov, A. D. FEBS Lett. 451, 157–161 (1999).

    Article  CAS  Google Scholar 

  12. Friedrich, T. & Weiss H. J. Theor. Biol. 187, 529–540 (1997).

    Article  CAS  Google Scholar 

  13. Hunte, C. et al. Nature 435, 1197–1202 (2005).

    Article  ADS  CAS  Google Scholar 

  14. Sazanov, L. A., Peak-Chew, S. Y., Fearnley, I. M. & Walker, J. E. Biochemistry 39, 7229–7235 (2000).

    Article  CAS  Google Scholar 

  15. Friedrich, T. J. Bioenerg. Biomembr. 33, 169–177 (2001).

    Article  CAS  Google Scholar 

  16. Yagi, T. & Matsuno-Yagi, A. Biochemistry 42, 2266–2274 (2003).

    Article  CAS  Google Scholar 

  17. Brandt, U. Annu. Rev. Biochem. 75, 69–92 (2006).

    Article  CAS  Google Scholar 

  18. Roth, R. & Hägerhäll, C. Biochim. Biophys. Acta 1504, 352–362 (2001).

    Article  CAS  Google Scholar 

  19. Nakamaru-Ogiso, E. et al. FEBS Lett. 584, 883–888 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry and Biophysics, Tomoko Ohnishi is in the Johnson Foundation, School of Medicine, University of Pennsylvania, Pennsylvania 19104, USA. ohnishi@mail.med.upenn.edu,

    Tomoko Ohnishi

Authors
  1. Tomoko Ohnishi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ohnishi, T. Piston drives a proton pump. Nature 465, 428–429 (2010). https://doi.org/10.1038/465428a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/465428a

  • Springer Nature Limited

This article is cited by

Search

Navigation