Researchers have met the challenge of capturing transient states of the SUMO E1 activating enzyme. Their pictures show radically different crystal structures for two of the steps in this enzyme's activity.
References
Haas, A. L. & Rose, I. A. J. Biol. Chem. 257, 10329–10337 (1982).
Haas, A. L., Warms, J. V., Hershko, A. & Rose, I. A. J. Biol. Chem. 257, 2543–2548 (1982).
Hershko, A., Heller, H., Elias, S. & Ciechanover, A. J. Biol. Chem. 258, 8206–8214 (1983).
Wilkinson, K. D. et al. Biochemistry 29, 7373–7380 (1990).
Pickart, C. M., Kasperek, E. M., Beal, R. & Kim, A. J. Biol. Chem. 269, 7115–7123 (1994).
Olsen, S. K., Capili, A. D., Lu, X., Tan, D. S. & Lima, C. D. Nature 463, 906–912 (2010).
Walden, H., Podgorski, M. S. & Schulman, B. A. Nature 422, 330–334 (2003).
Lois, L. M. & Lima, C. D. EMBO J. 24, 439–451 (2005).
Huang, D. T. et al. Nature 445, 394–398 (2007).
Lee, I. & Schindelin, H. Cell 134, 268–278 (2008).
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Schulman, B., Haas, A. Transformative encounters. Nature 463, 889–890 (2010). https://doi.org/10.1038/463889a
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DOI: https://doi.org/10.1038/463889a
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