The ring-shaped helicase enzyme Rho moves along RNA using ATP as an energy source. Coordinating ATP hydrolysis with nucleic-acid binding seems to determine the direction and mechanism of helicase movement.
References
Patel, S. S. & Picha, K. M. Annu. Rev. Biochem. 69, 651–697 (2000).
Thomsen, N. D. & Berger, J. M. Cell 139, 523–534 (2009).
Schwartz, A. et al. Nature Struct. Mol. Biol. doi:10.1038/nsmb.1711 (2009).
Skordalakes, E. & Berger, J. M. Cell 114, 135–146 (2003).
Wei, R. R. & Richardson, J. P. J. Biol. Chem. 276, 28380–28387 (2001).
Enemark, E. J. & Joshua-Tor, L. Nature 442, 270–275 (2006).
Boyer, P. D. Annu. Rev. Biochem. 66, 717–749 (1997).
Moffitt, J. R. et al. Nature 457, 446–450 (2009).
Donmez, I. & Patel, S. S. EMBO J. 27, 1718–1726 (2008).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Patel, S. Steps in the right direction. Nature 462, 581–583 (2009). https://doi.org/10.1038/462581a
Published:
Issue Date:
DOI: https://doi.org/10.1038/462581a
- Springer Nature Limited