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Activity acts locally

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How does neuronal activity affect the development of neural circuits? Work on the retina shows that blocking activity at the synapses between neurons reduces local synapse assembly without affecting global cellular structure.

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Figure 1: Blocking synaptic activity in the retina has local effects.

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Authors and Affiliations

  1. Jonathan B. Demb is in the Department of Ophthalmology and Visual Sciences, and the Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48105, USA. jdemb@umich.edu,

    Jonathan B. Demb

  2. Marla B. Feller is in the Department of Molecular and Cell Biology, and the Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA. mfeller@berkeley.edu,

    Marla B. Feller

Authors
  1. Jonathan B. Demb
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  2. Marla B. Feller
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Demb, J., Feller, M. Activity acts locally. Nature 460, 961–963 (2009). https://doi.org/10.1038/460961a

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