The ability of embryonic stem cells to give rise to any cell type relies on a remodelling protein that maintains open chromatin. But the chromatin landscape of these cells may be more complex than previously thought.
References
Jaenisch, R. & Young, R. Cell 132, 567–582 (2008).
Trojer, P. & Reinberg, D. Mol. Cell 28, 1–13 (2007).
Gaspar-Maia, A. et al. Nature 460, 863–868 (2009).
Meshorer, E. et al. Dev. Cell 10, 105–116 (2006).
Efroni, S. et al. Cell Stem Cell 2, 437–447 (2008).
Sims, R. J. III et al. Mol. Cell 28, 665–676 (2007).
Sims, R. J. III et al. J. Biol. Chem. 280, 41789–41792 (2005).
Flanagan, J. F. et al. Nature 438, 1181–1185 (2005).
Pavri, R. et al. Cell 125, 703–717 (2006).
Konev, A. Y. et al. Science 317, 1087–1090 (2007).
Zegerman, P., Canas, B., Pappin, D. & Kouzarides, T. J. Biol. Chem. 277, 11621–11624 (2002).
Nishioka, K. et al. Genes Dev. 16, 479–489 (2002).
Ooi, S. K. et al. Nature 448, 714–717 (2007).
Fazzio, T. G., Huff, J. T. & Panning, B. Cell 134, 162–174 (2008).
Berstein, B. E. et al. Cell 125, 315–326 (2006).
Mikkelsen, T. S. et al. Nature 454, 49–55 (2008).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sims III, R., Reinberg, D. Escaping fates with open states. Nature 460, 802–803 (2009). https://doi.org/10.1038/460802a
Published:
Issue Date:
DOI: https://doi.org/10.1038/460802a
- Springer Nature Limited