Skip to main content
Log in

Cancer

Three birds with one stone

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

The core domain of the p53 protein has been found to affect microRNA processing — its third known antitumour activity. Most cancerous p53 mutations affect this domain and may abolish all tumour-suppressor functions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Three antitumour functions.

References

  1. Toledo, F. & Wahl, G. M. Nature Rev. Cancer 6, 909–923 (2006).

    Article  CAS  Google Scholar 

  2. Green, D. R. & Kroemer, G. Nature 458, 1127–1130 (2009).

    Article  ADS  CAS  Google Scholar 

  3. Suzuki, H. I. et al. Nature 460, 529–533 (2009).

    Article  ADS  CAS  Google Scholar 

  4. Ventura, A. & Jacks, T. Cell 136, 586–591 (2009).

    Article  CAS  Google Scholar 

  5. He, L., He, X., Lowe, S. W. & Hannon, G. J. Nature Rev. Cancer 7, 819–822 (2007).

    Article  CAS  Google Scholar 

  6. Lozano, G. Curr. Opin. Genet. Dev. 17, 66–70 (2007).

    Article  CAS  Google Scholar 

  7. Suh, E.-K. et al. Nature 444, 624–628 (2006).

    Article  ADS  CAS  Google Scholar 

  8. Bourdon, J.-C. et al. Genes Dev. 19, 2122–2137 (2005).

    Article  CAS  Google Scholar 

  9. Whibley, C., Pharoah, P. D. P. & Hollstein, M. Nature Rev. Cancer 9, 95–107 (2009).

    Article  CAS  Google Scholar 

  10. Vazquez, A., Bond, E. E., Levine, A. J. & Bond, G. L. Nature Rev. Drug Discov. 7, 979–987 (2008).

    Article  CAS  Google Scholar 

  11. Vousden, K. H. & Lane, D. P. Nature Rev. Mol. Cell Biol. 8, 275–283 (2007).

    Article  CAS  Google Scholar 

  12. Fuller-Pace, F. V. Nucleic Acids Res. 34, 4206–4215 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Toledo, F., Bardot, B. Three birds with one stone. Nature 460, 466–467 (2009). https://doi.org/10.1038/460466a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/460466a

  • Springer Nature Limited

This article is cited by

Navigation