In many cancers, regulation of specific signalling molecules goes awry, affecting a host of other proteins and cellular processes. Proteomics is a useful systemic approach for identifying such extensive effects.
This is a preview of subscription content, log in via an institution to check access.
References
Old, W. M. et al. Mol. Cell 34, 115–131 (2009).
Gray-Schopfer, V., Wellbrock, C. & Marais, R. Nature 445, 851–857 (2007).
Hanahan, D. & Weinberg, R. A. Cell 100, 57–70 (2000).
Sarno, S. & Pinna, L. A. Mol. Biosyst. 4, 889–894 (2008).
Ritt, D. A. et al. Curr. Biol. 17, 179–184 (2007).
Garnett, M. J., Rana, S., Paterson, H., Barford, D. & Marais, R. Mol. Cell 20, 963–969 (2005).
Dumaz, N. et al. Cancer Res. 66, 9483–9491 (2006).
Specht, K. M. & Shokat, K. M. Curr. Opin. Cell Biol. 14, 155–159 (2002).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Huang, P., Marais, R. Melanoma troops massed. Nature 459, 336–337 (2009). https://doi.org/10.1038/459336a
Published:
Issue Date:
DOI: https://doi.org/10.1038/459336a
- Springer Nature Limited
This article is cited by
-
Targeted therapy in rare cancers—adopting the orphans
Nature Reviews Clinical Oncology (2012)
-
MicroRNA Expression Profiles Associated with Mutational Status and Survival in Malignant Melanoma
Journal of Investigative Dermatology (2010)
-
B-RAF Inhibitors: An Evolving Role in the Therapy of Malignant Melanoma
Current Oncology Reports (2010)