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Optical control of reward

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Is it wishful thinking that the behaviour of an organism as complex as a mouse might be controlled by modulating its intracellular signalling with light? No: this is just what researchers have achieved with an elegant technique.

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Figure 1: Light stimulation, intracellular signalling and regulation of function in neural networks.

References

  1. Airan, R. D., Thompson, K. R., Fenno, L. E., Bernstein, H. & Deisseroth, K. Nature 458, 1025–1029 (2009).

    Article  ADS  CAS  Google Scholar 

  2. Gradinaru, V. et al. J. Neurosci. 27, 14231–14238 (2007).

    Article  CAS  Google Scholar 

  3. Szobota, S. et al. Neuron 54, 535–545 (2007).

    Article  CAS  Google Scholar 

  4. Berndt, A., Yizhar, O., Gunaydin, L. A., Hegemann, P. & Deisseroth, K. Nature Neurosci. 12, 229–234 (2009).

    Article  CAS  Google Scholar 

  5. Cooper, J. R., Bloom, F. E. & Roth, R. H. in The Biochemical Basis of Neuropharmacology 8th edn (Oxford Univ. Press, 2003).

    Google Scholar 

  6. Bardo, M. T. & Bevins, R. A. Psychopharmacology 153, 31–43 (2000).

    Article  CAS  Google Scholar 

  7. Berridge, C. W. & Waterhouse, B. D. Brain Res. Brain Res. Rev. 42, 33–84 (2003).

    Article  Google Scholar 

  8. Surmeier, D. J., Ding, J., Day, M., Wang, Z. & Shen, W. Trends Neurosci. 30, 228–235 (2007).

    Article  CAS  Google Scholar 

  9. McClung, C. A. & Nestler, E. J. Neuropsychopharmacology 33, 3–17 (2008).

    Article  CAS  Google Scholar 

  10. Adamantidis, A. R., Zhang, F., Aravanis, A. M., Deisseroth, K. & de Lecea, L. Nature 450, 420–424 (2007).

    Article  ADS  CAS  Google Scholar 

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Moorman, D., Aston-Jones, G. Optical control of reward. Nature 458, 980–981 (2009). https://doi.org/10.1038/458980a

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