Targeting the blood vessels that feed tumours is not the silver bullet once hoped for, but refinements to the strategy may suggest further ways to treat the disease. Erika Check Hayden reports.
References
Folkman, J. N. Engl. J. Med. 285, 1182–1186 (1971).
Pàez-Ribes, M. et al. Cancer Cell 15, 220–231 (2009).
Ebos, J. M. L. et al. Cancer Cell 15, 232–239 (2009).
Reynolds, A. R. et al. Nature Med. doi:10.1038/nm.1941 (2009).
Pennacchietti, S. et al. Cancer Cell 3, 347–361 (2003).
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Hayden, E. Cutting off cancer's supply lines. Nature 458, 686–687 (2009). https://doi.org/10.1038/458686b
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DOI: https://doi.org/10.1038/458686b
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